Transient Bindingpockets for Research and Development, TRABITA

Professor Dr. Felix Hausch, scientific coordinator of the LOEWE project TRABITA, picture: Katrin Binner

Usually, drug molecules bind to specific therapeutic target proteins and thereby regulate their activity. Those proteins remain in their native conformation, however they form transient binding pockets temporarily. Often, drugs targeting these transient binding pockets have higher selectivity amongst other advantages, but on the downsides they are harder to discover.

The interdisciplinary consortium „Transient Bindingpockets for Research and Development, TRABITA“ was founded to facilitate the development of new therapeutic drugs for transient binding pockets. The project is supported by the Hessian Ministry of Science and Art, i.e. the LOEWE-Funding.

The RMU-project is designed to last for four years and is coordinated by the TU Darmstadt. The close cooperation with scientists of the Goethe-University Frankfurt and the university of applied scicences h_da is essential for the success of the project.

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